ENVIRONMENT

COMMUNICATIONS

Participant to the conference "polluants émergents, de nouveaux défis pour la gestion des eaux souterraines" in Orléans on the 19 and 20th of may 2016; presentation and stand

Participant to the Carrefour de l'eau conference, stand 380, Hall 4, 27-28 January 2016, Rennes, France

Participant to the Hydrogaia conference, stand, 27-28 may 2015, Monptellier, France

High resolution mass spectrometry metabolomic analyses for the screening of several hundred pollutants (drug residues and pesticides) in a single water sample, B. Corman, J.Cotton, F.Leroux, S. Broudin, C. Junot, C. Ducruix, Journée ASEES "L’ANALYSE  DE   L’EAU « Réflexions sur les suites à donner » " , Cochin Hospital, Paris , 27 November 2014 - Cahiers de l'Association Scientifique Européenne pour l'Eau et la Santé; http://dx.doi.org/10.1051/asees/2016006

Participant to the Journées Informations Eaux (JIE),  Flash session and stand, 4-5-6 November 2014, Poitiers

L’eau du robinet contient-elle des perturbateurs endocriniens ? Bruno Corman, Fanny Leroux, Jérôme Cotton, Simon Broudin, Christophe Junot, Céline Ducruix; Colloque Perturbateurs Endocriniens, juillet 2014, Romainville, France

Application de l’analyse métabolomique de contaminants organiques dans l’environnement par spectrométrie de masse haute résolution. Cotton J., Leroux F., Broudin S., Corman B., Junot C. and Ducruix C., Journées Scientifiques du RFMF, Lyon, 19-21 mai 2014.

Evaluation of drinking water purification processes by micro-pollutant detection using a comprehensive LC/Orbitrap mass spectrometry approach. Cotton J., Marie M., Madalinski G., Sabarly V., Masclet S., Perot J., Junot C. and Corman B., Food Metabolomics, Karlsruhe (Allemagne), 9-11 octobre 2011.

SCIENTIFIC PAPERS

Development and validation of a multiresidue method for the analysis of more than 500 pesticides and drugs in water based on on-line and liquid chromatography coupled to high resolution mass spectrometry, Jérôme Cotton, Fanny Leroux, Simon Broudin, Marion Poirel, Bruno Corman, Christophe Junot, Céline Ducruix, 2016, Water research, Volume 104, 1 November 2016, Pages 20–27, http://dx.doi.org/10.1016/j.watres.2016.07.075

Application of metabolomics to assess the micro-pollutant content of groundwater used for the production of drinking water;  J. Cotton, V. Sabarly, C. Ducruix, F. Nauleau, S. Masclet, S. Piel et C. Junot; TSM 2015 ; 1-2 : 21–31

GENERAL PUBLIC ARTICLES AND NEWS STORY

Le miel n’échappe pas à la pollution. (pay-to-view) 60 millions de consommateurs, octobre 2011, 464 : 30-35.

Polluants, sulfites : 52 vins à l’épreuve. (pay-to-view) 60 millions de consommateurs, mai 2012, 471 : 25-31.

HEALTH

COMMUNICATIONS

Association of metabolomic and lipidomic approaches for plasma biomarkers discovery. Seyer A., Boudah S., Broudin S., Ducruix C., Corman B., Junot C. and Colsch B., RD Connect, Heidelberg, 24-26 février 2014.

LC-ESI-FT/MS metabolomic analysis reveals molecular changes associated with the blood-brain barrier nano-TiO2 exposure. Madalinski G., Brun E., Desoubzdanne D., Oursel S., Sabarly V., Colsch B., Junot C. and Mabondzo A., Metabomeeting, Helsinki (Finlande), 25-28 septembre 2011.

Metabolomic study of inflammatory mediators by high resolution mass spectrometry-based method in a model of cyclophosphamide-induced acute bladder hypersensitivity. Desoubzdanne D., Oursel S., Madalinski G., Junot C., Lluel P. and Corman B., Metabomeeting, Helsinki (Finlande), 25-28 septembre 2011.

PAPERS

Annotation of the human cerebrospinal fluid lipidome using high resolution mass spectrometry and a dedicated data processing workflow. Seyer, A., Boudah, S., Broudin, S., Junot, C., Colsch, B. (2016) Metabolomics, 2016;12:91

Annotation of the human serum metabolome by coupling three liquid chromatography methods to high-resolution mass spectrometry  Boudah S, Olivier MF, Aros-Calt S, Oliveira L, Fenaille F, Tabet JC, Junot C., 2014, J Chromatogr B Analyt Technol Biomed Life Sci. ; 966:34-47

Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder, Augé C., Chene G., Dubourdeau M., Desoubzdanne D., Corman B., Palea S., Lluel P., Vergnolle N., Coelhod A-M., EJP, 2013, 707 (1-3) : 32-40.

Alterations of red blood cells metabolome in overhydrated hereditary stomatocytosis, Darghouth D., Koehl B., Heilier J-F., Madalinski G., Bovee P., Bosman G., Delaunay J., Junot C. and Romeo P-H., Haematologica, 2011, 96 (12) : 1861-65.

Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review. Roux A., Lison D., Junot C. and Heilier J-F., Clin. Biochem., 2011, 44 (1) : 119-35.

Pathophysiology of sickle cell disease is mirrored by the red blood cell metabolome. Darghouth D., Koehl B., Madalinski G., Heilier J-F., Bovee P., Xu Y., Olivier M-F., Bartolucci P., Benkerrou M., Pissard S., Colin Y., Galacteros F., Bosman G., Junot C. and Roméo P-H., Blood, 2011 , 117 (6) : 57-66.

Fourier transform mass spectrometry for metabolome analysis. Junot C., Madalinski G., Tabet J-C. and Ezan E., Analyst, 2010, 135 (9) : 2203-19.

Evaluation of accurate mass and relative isotopic abundance measurements in the LTQ-orbitrap mass spectrometer for further metabolomics database building. Xu Y., Heilier J-F., Madalinski G., Genin E., Ezan E., Tabet J-C. and Junot C., Anal. Chem., 2010, 82 (13) : 5490-501.

Mass spectrometry-based methods for the determination of sulfur and related metabolite concentrations in cell extracts. Godat E., Madalinski G., Muller L., Heilier J-F., Labarre J. and Junot C., Methods Enzymol., 2010, 473 : 41-76.

Mass spectrometry for the identification of the discriminating signals from metabolomics: current status and future trends. Werner E., Heilier J-F., Ducruix C., Ezan E., Junot C. and Tabet J-C., J. of Chromato. B., 2008, 871 (2) : 143-63.

Mass spectrometry-based metabolomics: accelerating the characterization of discriminating signals by combining statistical correlations and ultrahigh resolution. Werner E., Croixmarie V., Umbdenstock T., Ezan E., Chaminade P., Tabet J-C. and Junot C., Anal. Chem., 2008, 80 (13) : 4918-32.

Direct introduction of biological samples into a LTQ-Orbitrap hybrid mass spectrometer as a tool for fast metabolome analysis. Madalinski G., Godat E., Alves S., Lesage D., Genin E., Levi P., Labarre J., Tabet J-C., Ezan E. and Junot C., Anal. Chem., 2008, 80 (9) :  3291-303.

Combined proteome and metabolite-profiling analyses reveal surprising insights into yeast sulfur metabolism. Lafaye A., Junot C., Pereira Y., Lagniel G., Tabet J-C., Ezan E. and Labarre J., J. Biol. Chem. 2005, 280 (26) : 24723-30.

The early responses of Arabidopsis thaliana cells to cadmium exposure explored by protein and metabolite profiling analyses. Sarry J-E., Kuhn L., Ducruix C., Lafaye A., Junot C., Hugouvieux V., Jourdain A., Bastien O., Fiévet J-B., Vailhen D., Amekraz B., Moulin C, Ezan E., Garin J. and Bourguignon J., Proteomics, 2006, 6 (7) : 2180-98.

Metabolite profiling in rat urine by liquid chromatography/electrospray ion trap mass spectrometry. Application to the study of heavy metal toxicity. Lafaye A., Junot C., Ramounet-Le Gall B., Fritsch P., Tabet J-C. and Ezan E., Rapid Commun. Mass Spectrom., 2003, 17 (22) : 2541-9.